The truck in question is a 1994 F150 with a 351W [GT40 Heads, long tube headers] & a AODE 4x4.

What are the options to tuning this setup? Is the ECM able to be calibrated or would a harness swap using another Ford ECM be optimum? If a swap with ECM is the best solution, which one would be advised?

If it's not possible doing any of the above, what would make it possible? Looking to maximize efficiency & net reliable torque as it will be doing long hauls pulling a loaded 16' vehicle trailer at times.